ACE Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. Belongs to the peptidase M2 family. Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease
Chromosomal Location of human Ortholog: 17q23.3
Cellular Component:  basal plasma membrane; brush border membrane; endosome; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; lysosome; plasma membrane; sperm midpiece
Molecular Function:  bradykinin receptor binding; calmodulin binding; carboxypeptidase activity; chloride ion binding; endopeptidase activity; exopeptidase activity; heterocyclic compound binding; metallodipeptidase activity; metalloendopeptidase activity; metallopeptidase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase kinase binding; peptidase activity; peptidyl-dipeptidase activity; tripeptidyl-peptidase activity; zinc ion binding
Biological Process:  aging; amyloid-beta metabolic process; angiogenesis involved in coronary vascular morphogenesis; angiotensin maturation; animal organ regeneration; antigen processing and presentation of peptide antigen via MHC class I; arachidonic acid secretion; blood vessel diameter maintenance; blood vessel remodeling; bradykinin catabolic process; brain development; cell proliferation in bone marrow; cellular response to aldosterone; cellular response to glucose stimulus; eating behavior; embryo development ending in birth or egg hatching; female pregnancy; heart contraction; hematopoietic stem cell differentiation; hormone catabolic process; hormone metabolic process; kidney development; lung alveolus development; male gonad development; mononuclear cell proliferation; negative regulation of calcium ion import; negative regulation of gap junction assembly; negative regulation of gene expression; negative regulation of glucose import; negative regulation of protein binding; negative regulation of renal sodium excretion; neutrophil mediated immunity; peptide catabolic process; positive regulation of apoptotic process; positive regulation of inflammatory response; positive regulation of neurogenesis; positive regulation of peptidyl-cysteine S-nitrosylation; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of protein binding; positive regulation of protein tyrosine kinase activity; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; post-transcriptional regulation of gene expression; proteolysis; regulation of angiotensin metabolic process; regulation of blood pressure; regulation of hematopoietic stem cell proliferation; regulation of renal output by angiotensin; regulation of smooth muscle cell migration; regulation of synaptic plasticity; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; response to dexamethasone; response to hypoxia; response to laminar fluid shear stress; response to lipopolysaccharide; response to nutrient levels; response to thyroid hormone; response to xenobiotic stimulus; sensory perception of pain; spermatogenesis; substance P catabolic process; vasoconstriction
Disease: Hemorrhage, Intracerebral, Susceptibility To; Microvascular Complications Of Diabetes, Susceptibility To, 3; Renal Tubular Dysgenesis
Reference #:  P12821 (UniProtKB)
Alt. Names/Synonyms: ACE; ACE1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; Angiotensin-converting enzyme; Angiotensin-converting enzyme, soluble form; carboxycathepsin; CD143; CD143 antigen; DCP; DCP1; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; Kininase II; MGC26566; MVCD3; peptidase P; testicular ECA
Gene Symbols: ACE
Molecular weight: 149,715 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein