GABBR2 Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla (PubMed:10087195, PubMed:10328880, PubMed:10727622, PubMed:9872744). Weakly expressed in heart, testis and skeletal muscle (PubMed:10087195, PubMed:10727622). Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of rat Ortholog: 5q22
Cellular Component:  cytoplasm; dendrite; G protein-coupled GABA receptor complex; G protein-coupled receptor heterodimeric complex; GABA receptor complex; GABA-ergic synapse; glutamatergic synapse; neuron projection; perikaryon; plasma membrane; postsynaptic membrane; presynaptic membrane
Molecular Function:  G protein-coupled GABA receptor activity; protein binding; protein heterodimerization activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; neuron-glial cell signaling; synaptic transmission, GABAergic
Reference #:  O88871 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 51; G-protein coupled receptor 51; GABA-B R2 receptor; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gabbr2; GABR2; gamma-aminobutyric acid (GABA) B receptor 2; Gamma-aminobutyric acid type B receptor subunit 2; Gb2; Gpr51
Gene Symbols: Gabbr2
Molecular weight: 105,751 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene