GABBR2 Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla (PubMed:10087195, PubMed:10328880, PubMed:10727622, PubMed:9872744). Weakly expressed in heart, testis and skeletal muscle (PubMed:10087195, PubMed:10727622). Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 9q22.33
Cellular Component:  cytoplasm; G protein-coupled GABA receptor complex; G protein-coupled receptor heterodimeric complex; GABA receptor complex; neuron projection; plasma membrane; postsynaptic membrane
Molecular Function:  G protein-coupled GABA receptor activity; protein binding; protein heterodimerization activity; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; chemical synaptic transmission; G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; negative regulation of adenylate cyclase activity; neuron-glial cell signaling; synaptic transmission, GABAergic
Disease: Epileptic Encephalopathy, Early Infantile, 59; Neurodevelopmental Disorder With Poor Language And Loss Of Hand Skills; Tobacco Addiction, Susceptibility To
Reference #:  O75899 (UniProtKB)
Alt. Names/Synonyms: EIEE59; FLJ36928; G protein-coupled receptor 51; G-protein coupled receptor 51; GABA-B receptor 2; GABA-B receptor, R2 subunit; GABA-B-R2; GABA-BR2; GABABR2; GABBR2; GABR2; gamma-aminobutyric acid (GABA) B receptor, 2; gamma-aminobutyric acid B receptor 2; Gamma-aminobutyric acid type B receptor subunit 2; Gb2; GPR51; GPRC3B; HG20; HRIHFB2099; NDPLHS
Gene Symbols: GABBR2
Molecular weight: 105,821 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GABBR2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein