REXO2 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling. Belongs to the oligoribonuclease family. 3 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Hydrolase; Mitochondrial; Ribonuclease
Chromosomal Location of mouse Ortholog: 9|9 A5.3
Cellular Component:  focal adhesion; mitochondrion; nucleolus; nucleus
Molecular Function:  3'-5' exonuclease activity; 3'-5'-exoribonuclease activity; exonuclease activity; hydrolase activity; nuclease activity; nucleic acid binding
Biological Process:  nucleobase-containing compound metabolic process
Reference #:  Q9D8S4 (UniProtKB)
Alt. Names/Synonyms: 1810038D15Rik; AW107347; Oligoribonuclease, mitochondrial; ORN; Rex; Rex2; REX2, RNA exonuclease 2 homolog; REX2, RNA exonuclease 2 homolog (S. cerevisiae); Rexo2; RNA exonuclease 2; RNA exonuclease 2 homolog; Sfn; Small fragment nuclease; Smfn
Gene Symbols: Rexo2
Molecular weight: 26,739 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene