SF3B6
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. Belongs to the SF3B6 family. Note: This description may include information from UniProtKB.
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Protein type: RNA splicing; RNA-binding; Spliceosome |
Chromosomal Location of mouse Ortholog: 12|12 A1.1 |
Cellular Component:
catalytic step 2 spliceosome; nucleoplasm; nucleus; precatalytic spliceosome; spliceosomal complex; U12-type spliceosomal complex; U2 snRNP; U2-type spliceosomal complex
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Molecular Function:
mRNA binding; nucleic acid binding; RNA binding
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Biological Process:
blastocyst formation; mRNA processing; mRNA splicing, via spliceosome; RNA splicing
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Reference #:
P59708
(UniProtKB)
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Alt. Names/Synonyms: 0610009D07Rik; 6030419K15Rik; AV001342; PM14; Pre-mRNA branch site protein p14; RIKEN cDNA 0610009D07 gene; SF3b 14 kDa subunit; Sf3b1; Sf3b14; SF3B6; Splicing factor 3B subunit 6; splicing factor 3B, 14 kDa subunit; splicing factor 3B, subunit 6
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Gene Symbols: Sf3b6
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Molecular weight:
14,585 Da
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Basal Isoelectric point:
9.41
Predict pI for various phosphorylation states
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