PTGER4 Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family. High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 15 A1|15 1.99 cM
Cellular Component:  integral component of membrane; membrane; neuron projection terminus; neuronal cell body; nuclear membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; prostaglandin E receptor activity; prostaglandin receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; cellular response to prostaglandin E stimulus; chemokinesis; ductus arteriosus closure; ERK1 and ERK2 cascade; G protein-coupled receptor signaling pathway; inflammatory response; JNK cascade; negative regulation of circadian sleep/wake cycle, REM sleep; negative regulation of cytokine secretion; negative regulation of ductus arteriosus closure; negative regulation of endothelin secretion; negative regulation of eosinophil extravasation; negative regulation of hydrogen peroxide metabolic process; negative regulation of inflammatory response; negative regulation of integrin activation; negative regulation of interleukin-1 alpha secretion; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of peptide secretion; negative regulation of small intestine smooth muscle contraction; negative regulation of tumor necrosis factor production; negative regulation of tumor necrosis factor secretion; positive regulation of antral ovarian follicle growth; positive regulation of bone resorption; positive regulation of calcitonin secretion; positive regulation of cAMP-mediated signaling; positive regulation of cell adhesion; positive regulation of cell proliferation; positive regulation of chemokinesis; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of cytokine secretion; positive regulation of cytosolic calcium ion concentration; positive regulation of gene expression; positive regulation of hyaluronan biosynthetic process; positive regulation of inflammatory response; positive regulation of interleukin-10 secretion; positive regulation of interleukin-8 production; positive regulation of matrix metallopeptidase secretion; positive regulation of mucus secretion; positive regulation of neutrophil extravasation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of ovarian follicle development; positive regulation of protein phosphorylation; positive regulation of protein secretion; positive regulation of renal sodium excretion; positive regulation of smooth muscle cell migration; positive regulation of substance P secretion; positive regulation of substance P secretion, neurotransmission; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of urine volume; positive regulation of wound healing; regulation of circadian sleep/wake cycle, wakefulness; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide; signal transduction; T-helper cell differentiation
Reference #:  P32240 (UniProtKB)
Alt. Names/Synonyms: EP4; PE2R4; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (EP4 subtype); prostaglandin E receptor 4 (subtype EP4); prostaglandin E receptor EP4 subtype; Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; Ptger; Ptger4; Ptgerep4
Gene Symbols: Ptger4
Molecular weight: 56,158 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene