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PTGER4
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family. High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 5p13.1 |
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Cellular Component:
integral component of membrane; plasma membrane
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Molecular Function:
prostaglandin E receptor activity; protein binding
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Biological Process:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; ERK1 and ERK2 cascade; G protein-coupled receptor signaling pathway; immune response; JNK cascade; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; positive regulation of cytokine secretion; positive regulation of inflammatory response; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide; response to mechanical stimulus; T-helper cell differentiation
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Reference #:
P35408
(UniProtKB)
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Alt. Names/Synonyms: EP4; EP4R; MGC126583; PE2R4; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER2; PTGER4
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Gene Symbols: PTGER4
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Molecular weight:
53,120 Da
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Basal Isoelectric point:
9.08
Predict pI for various phosphorylation states
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