PTGER4 Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family. High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 5p13.1
Cellular Component:  integral component of membrane; plasma membrane
Molecular Function:  prostaglandin E receptor activity; protein binding
Biological Process:  adenylate cyclase-modulating G protein-coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; ERK1 and ERK2 cascade; G protein-coupled receptor signaling pathway; immune response; JNK cascade; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; positive regulation of cytokine secretion; positive regulation of inflammatory response; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide; response to mechanical stimulus; T-helper cell differentiation
Reference #:  P35408 (UniProtKB)
Alt. Names/Synonyms: EP4; EP4R; MGC126583; PE2R4; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER2; PTGER4
Gene Symbols: PTGER4
Molecular weight: 53,120 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB