DICER1 Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. Belongs to the helicase family. Dicer subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; EC; Helicase; RNA processing; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 12 E|12 54.83 cM
Cellular Component:  axon; cytoplasm; dendrite; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; growth cone; micro-ribonucleoprotein complex; nucleus; RISC complex; RISC-loading complex
Molecular Function:  ATP binding; deoxyribonuclease I activity; DNA binding; double-stranded RNA binding; endonuclease activity; endoribonuclease activity; endoribonuclease activity, producing 5'-phosphomonoesters; helicase activity; hydrolase activity; metal ion binding; miRNA binding; nuclease activity; nucleotide binding; pre-miRNA binding; protein binding; protein domain specific binding; ribonuclease III activity; RNA binding; siRNA binding
Biological Process:  anatomical structure development; angiogenesis; apoptotic DNA fragmentation; branching morphogenesis of an epithelial tube; cardiac muscle cell development; cardiac neural crest cell development involved in outflow tract morphogenesis; cartilage development; cell proliferation; cerebral cortex development; chromatin silencing at centromere outer repeat region; conversion of ds siRNA to ss siRNA; conversion of ds siRNA to ss siRNA involved in RNA interference; defense response to virus; digestive tract development; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; epidermis morphogenesis; ganglion development; gene silencing by RNA; hair follicle cell proliferation; hair follicle development; hair follicle morphogenesis; inner ear receptor cell development; intestinal epithelial cell development; lung development; meiotic spindle organization; miRNA loading onto RISC involved in gene silencing by miRNA; mRNA stabilization; multicellular organism growth; myoblast differentiation involved in skeletal muscle regeneration; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of Schwann cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; nerve development; neuron projection morphogenesis; NIK/NF-kappaB signaling; olfactory bulb interneuron differentiation; peripheral nervous system myelin formation; positive regulation of gene expression; positive regulation of miRNA metabolic process; positive regulation of myelination; positive regulation of Schwann cell differentiation; positive regulation of transcription by RNA polymerase II; post-embryonic development; pre-miRNA processing; production of miRNAs involved in gene silencing by miRNA; production of siRNA involved in RNA interference; regulation of cell cycle; regulation of cell differentiation; regulation of enamel mineralization; regulation of gene expression; regulation of inflammatory response; regulation of miRNA metabolic process; regulation of muscle cell apoptotic process; regulation of myelination; regulation of neurogenesis; regulation of neuron differentiation; regulation of Notch signaling pathway; regulation of odontogenesis of dentin-containing tooth; regulation of oligodendrocyte differentiation; regulation of protein phosphorylation; regulation of regulatory T cell differentiation; regulation of RNA metabolic process; regulation of stem cell differentiation; regulation of viral genome replication; reproductive structure development; RNA interference; RNA phosphodiester bond hydrolysis, endonucleolytic; RNA processing; rRNA catabolic process; siRNA loading onto RISC involved in RNA interference; spermatogonial cell division; spinal cord motor neuron differentiation; spindle assembly; spleen development; stem cell population maintenance; targeting of mRNA for destruction involved in RNA interference; trophectodermal cell proliferation; tube formation; zygote asymmetric cell division
Reference #:  Q8R418 (UniProtKB)
Alt. Names/Synonyms: 1110006F08Rik; D12Ertd7; D12Ertd7e; Dice; Dicer; dicer 1, ribonuclease type III; Dicer1; Dicer1, Dcr-1 homolog; Dicer1, Dcr-1 homolog (Drosophila); Double-strand-specific ribonuclease mDCR-1; Endoribonuclease Dicer; Mdcr; mKIAA0928
Gene Symbols: Dicer1
Molecular weight: 216,821 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene