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DICER1
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. Belongs to the helicase family. Dicer subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease |
| Chromosomal Location of mouse Ortholog: 12 E|12 54.83 cM |
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Cellular Component:
axon; cytoplasm; cytosol; dendrite; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; glutamatergic synapse; growth cone; nucleus; perinuclear region of cytoplasm; postsynaptic density, intracellular component; RISC complex; RISC-loading complex
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Molecular Function:
ATP binding; deoxyribonuclease I activity; DNA binding; double-stranded RNA binding; endonuclease activity; helicase activity; hydrolase activity; metal ion binding; miRNA binding; nuclease activity; nucleotide binding; pre-miRNA binding; protein binding; protein domain specific binding; ribonuclease III activity; RNA binding; RNA endonuclease activity; RNA endonuclease activity, producing 5'-phosphomonoesters; siRNA binding
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Biological Process:
anatomical structure development; angiogenesis; apoptotic DNA fragmentation; branching morphogenesis of an epithelial tube; cardiac muscle cell development; cardiac neural crest cell development involved in outflow tract morphogenesis; cartilage development; cell population proliferation; cerebral cortex development; defense response to virus; digestive tract development; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; epidermis morphogenesis; ganglion development; gene expression; global gene silencing by mRNA cleavage; hair follicle cell proliferation; hair follicle development; hair follicle morphogenesis; inner ear receptor cell development; intestinal epithelial cell development; lung development; meiotic spindle organization; miRNA processing; mRNA stabilization; multicellular organism growth; myoblast differentiation involved in skeletal muscle regeneration; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of Schwann cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; nerve development; neuron projection morphogenesis; NIK/NF-kappaB signaling; olfactory bulb interneuron differentiation; pericentric heterochromatin formation; peripheral nervous system myelin formation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; positive regulation of establishment of endothelial barrier; positive regulation of gene expression; positive regulation of hepatic stellate cell proliferation; positive regulation of miRNA metabolic process; positive regulation of myelination; positive regulation of Schwann cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial cell proliferation; post-embryonic development; pre-miRNA processing; regulation of cell cycle; regulation of enamel mineralization; regulation of epithelial cell differentiation; regulation of gene expression; regulation of inflammatory response; regulation of miRNA metabolic process; regulation of muscle cell apoptotic process; regulation of myelination; regulation of neurogenesis; regulation of neuron differentiation; regulation of Notch signaling pathway; regulation of odontogenesis of dentin-containing tooth; regulation of oligodendrocyte differentiation; regulation of protein phosphorylation; regulation of regulatory T cell differentiation; regulation of RNA metabolic process; regulation of stem cell differentiation; regulation of viral genome replication; regulatory ncRNA-mediated gene silencing; regulatory ncRNA-mediated post-transcriptional gene silencing; reproductive structure development; RISC complex assembly; RNA processing; rRNA processing; siRNA processing; spermatogonial cell division; spinal cord motor neuron differentiation; spindle assembly; spleen development; stem cell population maintenance; trophectodermal cell proliferation; zygote asymmetric cell division
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Reference #:
Q8R418
(UniProtKB)
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Alt. Names/Synonyms: 1110006F08Rik; D12Ertd7; D12Ertd7e; Dice; Dicer; dicer 1, ribonuclease type III; Dicer1; Dicer1, Dcr-1 homolog; Dicer1, Dcr-1 homolog (Drosophila); Double-strand-specific ribonuclease mDCR-1; Endoribonuclease Dicer; Mdcr; mKIAA0928
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Gene Symbols: Dicer1
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Molecular weight:
216,821 Da
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Basal Isoelectric point:
5.57
Predict pI for various phosphorylation states
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