SYNPO Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. Belongs to the synaptopodin family. Expressed in cerebral cortex. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component:  actin cytoskeleton; bicellular tight junction; glutamatergic synapse; nucleus; perikaryon; postsynaptic density; postsynaptic membrane; Schaffer collateral - CA1 synapse; spine apparatus; stress fiber; Z disc
Molecular Function:  actin binding
Biological Process:  modification of dendritic spine; positive regulation of actin filament bundle assembly; positive regulation of postsynaptic cytosolic calcium concentration; postsynaptic modulation of chemical synaptic transmission; regulation of long-term neuronal synaptic plasticity; regulation of stress fiber assembly; spine apparatus assembly; visual learning
Reference #:  Q9Z327 (UniProtKB)
Alt. Names/Synonyms: Synaptopodin; Synpo
Gene Symbols: Synpo
Molecular weight: 99,986 Da
Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene