NUDT5 Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Belongs to the Nudix hydrolase family. Widely expressed. Most abundant in liver. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Nucleotide Metabolism - purine; Phosphatase
Chromosomal Location of Human Ortholog: 2|2 A1
Cellular Component:  nucleus
Molecular Function:  8-oxo-dGDP phosphatase activity; ADP-ribose diphosphatase activity; ADP-sugar diphosphatase activity; hydrolase activity; magnesium ion binding; metal ion binding; nucleoside-diphosphatase activity; nucleotidyltransferase activity; protein homodimerization activity; RNA binding; snoRNA binding; transferase activity
Biological Process:  ATP generation from poly-ADP-D-ribose; chromatin remodeling; D-ribose catabolic process; nucleobase-containing compound metabolic process; nucleoside phosphate metabolic process; ribonucleoside diphosphate catabolic process; ribose phosphate metabolic process
Reference #:  Q9JKX6 (UniProtKB)
Alt. Names/Synonyms: 8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; Nudix motif 5; Nudt5; OTTMUSP00000011662
Gene Symbols: Nudt5
Molecular weight: 23,984 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene