|
TCF20
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor |
| Chromosomal Location of mouse Ortholog: 15|15 E1 |
|
Cellular Component:
nuclear body; nucleoplasm; nucleus
|
|
Molecular Function:
DNA binding; DNA-binding transcription factor activity; metal ion binding; transcription cis-regulatory region binding; transcription coactivator activity
|
|
Biological Process:
DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
|
|
Reference #:
Q9EPQ8
(UniProtKB)
|
|
Alt. Names/Synonyms: 2810438H08Rik; mKIAA0292; Nuclear factor SPBP; Spbp; SPRE-binding protein; stromelysin 1 PDGF responsive element binding protein; stromelysin 1 PDGF-responsive element-binding protein; stromelysin PDGF responsive element binding protein transcription factor; Stromelysin-1 PDGF-responsive element-binding protein; TCF-20; Tcf20; Transcription factor 20
|
|
Gene Symbols: Tcf20
|
|
Molecular weight:
215,683 Da
|
|
Basal Isoelectric point:
9.12
Predict pI for various phosphorylation states
|
|
CST Pathways:
Adherens Junction Dynamics
|
Wnt/ß-Catenin Signaling
|
