TCF20 Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 15|15 E1
Cellular Component:  nuclear body; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; metal ion binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  positive regulation of transcription by RNA polymerase II
Reference #:  Q9EPQ8 (UniProtKB)
Alt. Names/Synonyms: 2810438H08Rik; mKIAA0292; Nuclear factor SPBP; Spbp; SPRE-binding protein; stromelysin 1 PDGF responsive element binding protein; stromelysin 1 PDGF-responsive element-binding protein; stromelysin PDGF responsive element binding protein transcription factor; Stromelysin-1 PDGF-responsive element-binding protein; TCF-20; Tcf20; Transcription factor 20
Gene Symbols: Tcf20
Molecular weight: 215,683 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below

TCF20

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA