|
PCID2
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells. Belongs to the CSN12 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 8|8 A1.1 |
|
Cellular Component:
cytoplasm; nuclear pore nuclear basket; nucleus; transcription export complex 2
|
|
Molecular Function:
double-stranded DNA binding; RNA binding
|
|
Biological Process:
negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity; nuclear retention of pre-mRNA at the site of transcription; poly(A)+ mRNA export from nucleus; positive regulation of B cell differentiation; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of transcription, DNA-templated; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery; regulation of mRNA stability; spleen development; transcription elongation from RNA polymerase II promoter
|
|
Reference #:
Q8BFV2
(UniProtKB)
|
|
Alt. Names/Synonyms: A730042J05Rik; CSN12-like protein; PCI domain containing 2; PCI domain-containing protein 2; Pcid2
|
|
Gene Symbols: Pcid2
|
|
Molecular weight:
46,132 Da
|
|
Basal Isoelectric point:
8.78
Predict pI for various phosphorylation states
|
