PHPT1 Exhibits phosphohistidine phosphatase activity. Belongs to the janus family. Expressed abundantly in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.-; Motility/polarity/chemotaxis; Phosphatase
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component:  cytoplasm; cytosol
Molecular Function:  calcium channel inhibitor activity; hydrolase activity; ion channel binding; phosphoprotein phosphatase activity; protein histidine phosphatase activity
Biological Process:  negative regulation of ATP citrate synthase activity; negative regulation of lyase activity; negative regulation of T cell receptor signaling pathway; peptidyl-histidine dephosphorylation; positive regulation of cell motility; positive regulation of insulin secretion involved in cellular response to glucose stimulus; protein dephosphorylation; regulation of actin cytoskeleton reorganization
Reference #:  Q9DAK9 (UniProtKB)
Alt. Names/Synonyms: 14 kDa phosphohistidine phosphatase; 1700008C22Rik; OTTMUSP00000013112; Phosphohistidine phosphatase 1; PHP; Php14; Phpt1; Protein histidine phosphatase
Gene Symbols: Phpt1
Molecular weight: 13,997 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene