NIT2 Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle. Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.1.3; Hydrolase; Mitochondrial
Chromosomal Location of Human Ortholog: 16 C1.1|16 34.22 cM
Cellular Component:  centrosome; cytoplasm; cytosol
Molecular Function:  hydrolase activity; omega-amidase activity
Biological Process:  asparagine metabolic process; glutamine metabolic process; nitrogen compound metabolic process; oxaloacetate metabolic process
Reference #:  Q9JHW2 (UniProtKB)
Alt. Names/Synonyms: 1190017B19Rik; D16Ertd502; D16Ertd502e; Nit protein 2; Nit2; nitrilase family, member 2; Nitrilase homolog 2; Omega-amidase NIT2
Gene Symbols: Nit2
Molecular weight: 30,502 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
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NIT2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene