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GAREM
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. Isoform 1 is ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 18|18 A2 |
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Cellular Component:
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Molecular Function:
proline-rich region binding
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Biological Process:
cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade
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Reference #:
Q3UFT3
(UniProtKB)
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Alt. Names/Synonyms: FA59A; Fam5; Fam59a; family with sequence similarity 59, member A; GARE1; GAREM; Garem1; Gm944; GRB2 associated regulator of MAPK1 subtype 1; GRB2 associated, regulator of MAPK1; GRB2-associated and regulator of MAPK protein; GRB2-associated and regulator of MAPK1; Kiaa4238; mKIAA4238; Protein FAM59A
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Gene Symbols: Garem1
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Molecular weight:
97,250 Da
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Basal Isoelectric point:
6.17
Predict pI for various phosphorylation states
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