GAREM Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. Isoform 1 is ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 18|18 A2
Cellular Component: 
Molecular Function:  proline-rich region binding
Biological Process:  cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade
Reference #:  Q3UFT3 (UniProtKB)
Alt. Names/Synonyms: C86169; FA59A; Fam59a; family with sequence similarity 59, member A; GAREM; Gm944; GRB2-associated and regulator of MAPK protein; hypothetical protein LOC381126; Kiaa4238; mKIAA4238; Protein FAM59A
Gene Symbols: Fam59a
Molecular weight: 97,250 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
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GAREM

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene