PSMB7 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. Belongs to the peptidase T1B family. Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 2 B|2 24.42 cM
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function:  endopeptidase activity; hydrolase activity; peptidase activity; threonine-type endopeptidase activity
Biological Process:  proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process
Reference #:  P70195 (UniProtKB)
Alt. Names/Synonyms: AU020723; Macropain chain Z; MC14; Mmc14; Multicatalytic endopeptidase complex chain Z; OTTMUSP00000013820; proteasome (prosome, macropain) subunit, beta type 7; Proteasome subunit beta type-7; Proteasome subunit Z; PSB7; Psmb7
Gene Symbols: Psmb7
Molecular weight: 29,891 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSMB7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene