GCN5 Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context. Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Acetylation of histones gives a specific tag for epigenetic transcription activation. Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling. Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression. Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Belongs to the acetyltransferase family. GCN5 subfamily. Expressed in all tissues tested, with most abundant expression in ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 2.3.1.48
Chromosomal Location of Human Ortholog: 11 D|11 63.53 cM
Cellular Component:  Ada2/Gcn5/Ada3 transcription activator complex; centrosome; chromosome; cytoplasm; cytoskeleton; histone acetyltransferase complex; mitotic spindle; nuclear chromatin; nucleus; STAGA complex; transcription factor TFTC complex
Molecular Function:  acetyltransferase activity; chromatin binding; H3 histone acetyltransferase activity; histone acetyltransferase activity; histone acetyltransferase activity (H4-K12 specific); histone deacetylase binding; histone succinyltransferase activity; N-acetyltransferase activity; peptide-lysine-N-acetyltransferase activity; protein binding; protein phosphatase binding; transcription coactivator activity; transcription factor binding; transferase activity; transferase activity, transferring acyl groups
Biological Process:  alpha-tubulin acetylation; cell proliferation; cytokine production; histone acetylation; histone deubiquitination; histone H3 acetylation; histone H3-K14 acetylation; histone H4-K12 acetylation; histone succinylation; in utero embryonic development; internal peptidyl-lysine acetylation; intracellular distribution of mitochondria; long-term memory; metencephalon development; midbrain development; multicellular organism growth; negative regulation of centriole replication; nervous system development; neural tube closure; positive regulation of cardiac muscle cell differentiation; positive regulation of cell projection organization; positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; positive regulation of transcription by RNA polymerase II; regulation of protein stability; regulation of regulatory T cell differentiation; regulation of synaptic plasticity; regulation of T cell activation; regulation of transcription, DNA-templated; somitogenesis; telencephalon development
Reference #:  Q9JHD2 (UniProtKB)
Alt. Names/Synonyms: 1110051E14Rik; AW212720; Gcn; Gcn5; GCN5 general control of amino acid synthesis-like 2; Gcn5l2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5-like 2; general control of amino acid synthesis, yeast homolog-like 2; general control of amino acid synthesis-like 2; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; K(lysine) acetyltransferase 2A; Kat2a; Lysine acetyltransferase 2A; MmGCN5; OTTMUSP00000001992; OTTMUSP00000001993; PCAF-B/G; PCAF-B/GCN5; RP23-390D17.6
Gene Symbols: Kat2a
Molecular weight: 93,394 Da
Basal Isoelectric point: 9.2  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GCN5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene