GCN5
Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context. Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Acetylation of histones gives a specific tag for epigenetic transcription activation. Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling. Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression. Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Belongs to the acetyltransferase family. GCN5 subfamily. Expressed in all tissues tested, with most abundant expression in ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Acetyltransferase; EC 2.3.1.48 |
Chromosomal Location of mouse Ortholog: 11 D|11 63.53 cM |
Cellular Component:
ATAC complex; centrosome; chromatin; chromosome; cytoplasm; cytoskeleton; histone acetyltransferase complex; mitotic spindle; nucleus; oxoglutarate dehydrogenase complex; SAGA complex; transcription factor TFTC complex
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Molecular Function:
acetyltransferase activity; acyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; chromatin binding; DNA-binding transcription factor binding; histone acetyltransferase activity; histone deacetylase binding; histone glutaryltransferase activity; histone H3 acetyltransferase activity; histone H3K18 acetyltransferase activity; histone H3K9 acetyltransferase activity; histone H4K12 acetyltransferase activity; histone succinyltransferase activity; N-acetyltransferase activity; peptide-lysine-N-acetyltransferase activity; protein binding; protein phosphatase binding; transcription coactivator activity; transferase activity
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Biological Process:
alpha-tubulin acetylation; chromatin remodeling; fibroblast proliferation; gluconeogenesis; histone acetylation; histone H3 acetylation; histone H3-K14 acetylation; histone succinylation; in utero embryonic development; internal peptidyl-lysine acetylation; intracellular distribution of mitochondria; long-term memory; metencephalon development; midbrain development; monoubiquitinated histone deubiquitination; monoubiquitinated histone H2A deubiquitination; multicellular organism growth; negative regulation of centriole replication; negative regulation of gluconeogenesis; nervous system development; neural tube closure; peptidyl-lysine glutarylation; positive regulation of cardiac muscle cell differentiation; positive regulation of cell projection organization; positive regulation of cytokine production; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of transcription by RNA polymerase II; regulation of bone development; regulation of cartilage development; regulation of cell cycle; regulation of cell division; regulation of DNA repair; regulation of DNA-templated transcription; regulation of embryonic development; regulation of histone deacetylation; regulation of protein stability; regulation of regulatory T cell differentiation; regulation of RNA splicing; regulation of stem cell population maintenance; regulation of synaptic plasticity; regulation of T cell activation; regulation of transcription by RNA polymerase II; regulation of tubulin deacetylation; somitogenesis; telencephalon development
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Reference #:
Q9JHD2
(UniProtKB)
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Alt. Names/Synonyms: 1110051E14Rik; AW212720; Gcn; Gcn5; GCN5 general control of amino acid synthesis-like 2; Gcn5l2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5-like 2; general control of amino acid synthesis, yeast homolog-like 2; general control of amino acid synthesis-like 2; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; K(lysine) acetyltransferase 2A; Kat2a; Lysine acetyltransferase 2A; MmGCN5; OTTMUSP00000001992; OTTMUSP00000001993; PCAF-B/G; PCAF-B/GCN5; RP23-390D17.6
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Gene Symbols: Kat2a
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Molecular weight:
93,394 Da
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Basal Isoelectric point:
9.2
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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