C3aR Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Belongs to the G-protein coupled receptor 1 family. Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6|6 F2
Cellular Component:  integral component of membrane; membrane; plasma membrane
Molecular Function:  complement component C3a binding; complement component C3a receptor activity; complement receptor activity; G protein-coupled receptor activity
Biological Process:  chemotaxis; complement receptor mediated signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of DNA biosynthetic process; positive regulation of glomerular mesangial cell proliferation; positive regulation of macrophage chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of vascular endothelial growth factor production; regulation of blood pressure; signal transduction; tolerance induction to nonself antigen
Reference #:  O09047 (UniProtKB)
Alt. Names/Synonyms: anaphylatoxin C3a receptor; AZ3B; C3a anaphylatoxin chemotactic receptor; C3a-R; C3AR; C3ar1; C3r1; Complement component 3a receptor 1; HNFAG09
Gene Symbols: C3ar1
Molecular weight: 53,576 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene