PDCD4 protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Tumor suppressor
Chromosomal Location of Human Ortholog: 19 D2|19 48.73 cM
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  protein binding; RNA binding
Biological Process:  apoptosis; BMP signaling pathway; cell aging; negative regulation of apoptosis; negative regulation of cytokine production involved in inflammatory response; negative regulation of myofibroblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of vascular smooth muscle cell differentiation; negative regulation of vascular smooth muscle cell proliferation; positive regulation of endothelial cell apoptotic process; positive regulation of inflammatory response; positive regulation of NIK/NF-kappaB signaling; positive regulation of smooth muscle cell apoptotic process; positive regulation of vascular associated smooth muscle cell apoptotic process; regulation of protein metabolic process
Reference #:  Q61823 (UniProtKB)
Alt. Names/Synonyms: D19Ucla1; Ma3; Pdcd4; programmed cell death 4; Programmed cell death protein 4; Protein MA-3; Tis; Topoisomerase-inhibitor suppressed protein
Gene Symbols: Pdcd4
Molecular weight: 51,702 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene