|
PDCD4
protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified. Note: This description may include information from UniProtKB.
|
| Protein type: Apoptosis; Tumor suppressor |
| Chromosomal Location of Human Ortholog: 19 D2|19 48.73 cM |
|
Cellular Component:
cytoplasm; cytosol; nucleus
|
|
Molecular Function:
protein binding; RNA binding
|
|
Biological Process:
apoptosis; BMP signaling pathway; cell aging; negative regulation of apoptosis; negative regulation of cytokine production involved in inflammatory response; negative regulation of myofibroblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of vascular smooth muscle cell differentiation; negative regulation of vascular smooth muscle cell proliferation; positive regulation of endothelial cell apoptotic process; positive regulation of inflammatory response; positive regulation of NIK/NF-kappaB signaling; positive regulation of smooth muscle cell apoptotic process; positive regulation of vascular associated smooth muscle cell apoptotic process; regulation of protein metabolic process
|
|
Reference #:
Q61823
(UniProtKB)
|
|
Alt. Names/Synonyms: D19Ucla1; Ma3; Pdcd4; programmed cell death 4; Programmed cell death protein 4; Protein MA-3; Tis; Topoisomerase-inhibitor suppressed protein
|
|
Gene Symbols: Pdcd4
|
|
Molecular weight:
51,702 Da
|
|
Basal Isoelectric point:
5.04
Predict pI for various phosphorylation states
|
|
CST Pathways:
PI3K/Akt Signaling
|
Translation: eIF4E and p70S6K
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
