PSMB8 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. Belongs to the peptidase T1B family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 17 B1|17 17.98 cM
Cellular Component:  cytoplasm; nucleus; proteasome complex; proteasome core complex; spermatoproteasome complex
Molecular Function:  endopeptidase activity; hydrolase activity; peptidase activity; threonine-type endopeptidase activity
Biological Process:  antigen processing and presentation; cell differentiation; fat cell differentiation; immune system process; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of endopeptidase activity
Reference #:  P28063 (UniProtKB)
Alt. Names/Synonyms: large multifunctional protease 7; Lmp-7; Lmp7; Low molecular mass protein 7; Macropain subunit C13; Mc13; MC13 (LMP7); Multicatalytic endopeptidase complex subunit C13; proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); Proteasome component C13; Proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit MC13; proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteosome beta 8 subunit; PSB8; Psmb8
Gene Symbols: Psmb8
Molecular weight: 30,260 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene