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TBC1D1
May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Rab; Ubiquitin-specific protease |
| Chromosomal Location of mouse Ortholog: 5 C3.1|5 32.8 cM |
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Cellular Component:
cytosol; nucleus
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Molecular Function:
GTPase activator activity; protein binding
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Biological Process:
activation of GTPase activity; negative regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of protein localization
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Reference #:
Q60949
(UniProtKB)
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Alt. Names/Synonyms: 1110062G02Rik; AI385682; AW555803; Kiaa1108; MGC106104; MGC144097; mKIAA1108; Nob; Nob1; Nobq1; Tbc1; TBC1 domain family member 1; TBC1 domain family, member 1; Tbc1d1; TBCD1; tre-2/USP6, BUB2, cdc16) domain family, member 1
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Gene Symbols: Tbc1d1
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Molecular weight:
142,026 Da
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Basal Isoelectric point:
6.84
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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