TRXR1 Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  cytoplasm; cytosol; fibrillar center; mitochondrion; neuronal cell body; nucleoplasm; nucleus
Molecular Function:  electron transfer activity; flavin adenine dinucleotide binding; mercury ion binding; NAD(P)H oxidase activity; oxidoreductase activity; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor; protein homodimerization activity; selenate reductase activity; thioredoxin-disulfide reductase activity
Biological Process:  benzene-containing compound metabolic process; cell proliferation; cell redox homeostasis; gastrulation; hydrogen peroxide catabolic process; mesoderm formation; NADPH oxidation; positive regulation of cell death; protein tetramerization; response to oxidative stress; selenocysteine metabolic process
Reference #:  Q9JMH6 (UniProtKB)
Alt. Names/Synonyms: thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; Thioredoxin reductase TR1; TR alpha; TR1; Trx; Trxr1; Txnrd1
Gene Symbols: Txnrd1
Molecular weight: 67,084 Da
Basal Isoelectric point: 7.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene