SYNJ1 Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phosphatase, lipid; Vesicle
Chromosomal Location of rat Ortholog: 11q11
Cellular Component:  clathrin coat of coated pit; cytoplasm; glutamatergic synapse; membrane coat; neuron projection; parallel fiber to Purkinje cell synapse; perinuclear region of cytoplasm; presynapse; protein-containing complex; Schaffer collateral - CA1 synapse; synaptic membrane; terminal bouton; vesicle membrane
Molecular Function:  EH domain binding; inositol-1,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol phosphate 5-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; protein binding; protein C-terminus binding; protein-containing complex binding; RNA binding; SH3 domain binding
Biological Process:  brain development; inositol phosphate dephosphorylation; learning; neurotransmitter transport; phosphatidylinositol dephosphorylation; phosphatidylinositol metabolic process; positive regulation of endosome organization; positive regulation of gliogenesis; positive regulation of receptor-mediated endocytosis; postsynaptic neurotransmitter receptor internalization; regulation of postsynaptic neurotransmitter receptor internalization; response to cytokine; response to retinoic acid; synaptic vesicle endocytosis; synaptic vesicle priming; synaptic vesicle transport; synaptic vesicle uncoating
Reference #:  Q62910 (UniProtKB)
Alt. Names/Synonyms: Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1; synaptojanin 1; Synaptojanin-1; Synj1
Gene Symbols: Synj1
Molecular weight: 172,881 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene