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SYNJ1
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Motility/polarity/chemotaxis; Phosphatase, lipid; Vesicle |
| Chromosomal Location of human Ortholog: 21q22.11 |
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Cellular Component:
clathrin coat of coated pit; cytosol; membrane coat; microtubule; perinuclear region of cytoplasm; presynapse; synaptic membrane; terminal bouton; vesicle membrane
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Molecular Function:
inositol-1,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol phosphate 4-phosphatase activity; phosphatidylinositol phosphate 5-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; RNA binding; SH3 domain binding
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Biological Process:
inositol phosphate metabolic process; learning; membrane organization; neurotransmitter transport; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol metabolic process; phosphatidylinositol-3-phosphate biosynthetic process; positive regulation of endosome organization; synaptic vesicle endocytosis; synaptic vesicle priming; synaptic vesicle transport; synaptic vesicle uncoating
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Disease: Epileptic Encephalopathy, Early Infantile, 53; Parkinson Disease 20, Early-onset
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Reference #:
O43426
(UniProtKB)
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Alt. Names/Synonyms: EIEE53; inositol 5'-phosphatase (synaptojanin 1); inositol polyphosphate-5-phosphatase G; INPP5G; KIAA0910; PARK20; phosphoinositide 5-phosphatase; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1; synaptojanin 1; Synaptojanin-1; synaptojanin-1, polyphosphoinositide phosphatase; SYNJ1
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Gene Symbols: SYNJ1
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Molecular weight:
173,103 Da
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Basal Isoelectric point:
7.13
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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