SYNJ1 Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phosphatase, lipid; Vesicle
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component:  clathrin coat of coated pit; cytosol; membrane coat; perinuclear region of cytoplasm; presynapse; synaptic membrane; terminal bouton; vesicle membrane
Molecular Function:  phosphatidylinositol phosphate 5-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; RNA binding
Biological Process:  inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning; membrane organization; neurotransmitter transport; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol metabolic process; positive regulation of endosome organization; synaptic vesicle endocytosis; synaptic vesicle priming; synaptic vesicle transport; synaptic vesicle uncoating
Disease: Epileptic Encephalopathy, Early Infantile, 53; Parkinson Disease 20, Early-onset
Reference #:  O43426 (UniProtKB)
Alt. Names/Synonyms: EIEE53; inositol 5'-phosphatase (synaptojanin 1); inositol polyphosphate-5-phosphatase G; INPP5G; KIAA0910; PARK20; phosphoinositide 5-phosphatase; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1; synaptojanin 1; Synaptojanin-1; synaptojanin-1, polyphosphoinositide phosphatase; SYNJ1
Gene Symbols: SYNJ1
Molecular weight: 173,103 Da
Basal Isoelectric point: 7.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB