|
HDAC8
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. Belongs to the histone deacetylase family. HD type 1 subfamily. Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Deacetylase; EC 3.5.1.98; Hydrolase |
| Chromosomal Location of mouse Ortholog: X|X D |
|
Cellular Component:
chromosome; cytoplasm; histone deacetylase complex; nucleus
|
|
Molecular Function:
chromatin binding; deacetylase activity; DNA-binding transcription factor binding; histone deacetylase activity; histone decrotonylase activity; Hsp70 protein binding; Hsp90 protein binding; hydrolase activity; metal ion binding; protein lysine deacetylase activity
|
|
Biological Process:
cellular response to forskolin; cellular response to trichostatin A; chromatin organization; histone deacetylation; mitotic sister chromatid cohesion; negative regulation of gene expression; negative regulation of histone H3-K9 acetylation; negative regulation of osteoblast differentiation; negative regulation of protein ubiquitination; regulation of protein stability; regulation of telomere maintenance; response to 11-deoxycorticosterone
|
|
Reference #:
Q8VH37
(UniProtKB)
|
|
Alt. Names/Synonyms: 2610007D20Rik; HD8; Hdac8; Histone deacetylase 8
|
|
Gene Symbols: Hdac8
|
|
Molecular weight:
41,772 Da
|
|
Basal Isoelectric point:
5.73
Predict pI for various phosphorylation states
|
|
CST Pathways:
G1/S Checkpoint
|
NF-kB Signaling
|
Protein Acetylation
|
Wnt/ß-Catenin Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
