HDAC8 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. Belongs to the histone deacetylase family. HD type 1 subfamily. Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC; Hydrolase
Chromosomal Location of human Ortholog: Xq13.1
Cellular Component:  cytoplasm; histone deacetylase complex; nuclear chromosome; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor binding; histone deacetylase activity; histone decrotonylase activity; Hsp70 protein binding; Hsp90 protein binding; metal ion binding; protein binding
Biological Process:  chromatin organization; histone deacetylation; negative regulation of protein ubiquitination; negative regulation of transcription by RNA polymerase II; regulation of cohesin loading; regulation of protein stability; regulation of telomere maintenance; regulation of transcription by RNA polymerase II; sister chromatid cohesion
Disease: Cornelia De Lange Syndrome 5
Reference #:  Q9BY41 (UniProtKB)
Alt. Names/Synonyms: CDA07; CDLS5; HD8; HDAC8; HDACL1; Histone deacetylase 8; histone deacetylase-like 1; KDAC8; MRXS6; RPD3; WTS
Gene Symbols: HDAC8
Molecular weight: 41,758 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein