GDI1 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. Belongs to the Rab GDI family. Brain; predominant in neural and sensory tissues. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: X A7.3|X 37.97 cM
Cellular Component:  axon; cytoplasm; Golgi apparatus; midbody; myelin sheath; neuron projection; neuronal cell body; protein-containing complex
Molecular Function:  GDP-dissociation inhibitor activity; GTPase activator activity; Rab GDP-dissociation inhibitor activity; Rab GTPase binding
Biological Process:  negative regulation of axonogenesis; negative regulation of protein targeting to membrane; positive regulation of axon extension; protein transport; response to calcium ion; small GTPase mediated signal transduction; vesicle-mediated transport
Reference #:  P50396 (UniProtKB)
Alt. Names/Synonyms: GDI-1; Gdi1; GDIA; GDIalpha; guanosine diphosphate (GDP) dissociation inhibitor 1; Guanosine diphosphate dissociation inhibitor 1; MGC21593; OTTMUSP00000019266; Rab GDI alpha; Rab GDIalpha; Rab GDP dissociation inhibitor alpha; Rabgdia
Gene Symbols: Gdi1
Molecular weight: 50,522 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene