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GDI1
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. Belongs to the Rab GDI family. Brain; predominant in neural and sensory tissues. Note: This description may include information from UniProtKB.
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| Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: X A7.3|X 37.97 cM |
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Cellular Component:
axon; cytoplasm; Golgi apparatus; midbody; myelin sheath; neuron projection; neuronal cell body; protein-containing complex
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Molecular Function:
GDP-dissociation inhibitor activity; GTPase activator activity; Rab GDP-dissociation inhibitor activity; Rab GTPase binding
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Biological Process:
negative regulation of axonogenesis; negative regulation of protein targeting to membrane; positive regulation of axon extension; protein transport; response to calcium ion; small GTPase mediated signal transduction; vesicle-mediated transport
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Reference #:
P50396
(UniProtKB)
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Alt. Names/Synonyms: GDI-1; Gdi1; GDIA; GDIalpha; guanosine diphosphate (GDP) dissociation inhibitor 1; Guanosine diphosphate dissociation inhibitor 1; MGC21593; OTTMUSP00000019266; Rab GDI alpha; Rab GDIalpha; Rab GDP dissociation inhibitor alpha; Rabgdia
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Gene Symbols: Gdi1
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Molecular weight:
50,522 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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