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GDI1
a GDP dissociation inhibitor protein expressed primarily in neural and sensory tissues. GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the Rab family, small GTP-binding proteins of the Ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from Rab proteins and release GDP from membrane-bound Rabs. Mutations have been linked to X-linked nonspecific mental retardation. Note: This description may include information from UniProtKB.
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| Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: X A7.3|X 37.97 cM |
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Cellular Component:
axon; cytoplasm; Golgi apparatus; midbody; myelin sheath; neuron projection; neuronal cell body; protein-containing complex
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Molecular Function:
GDP-dissociation inhibitor activity; GTPase activator activity; Rab GDP-dissociation inhibitor activity; Rab GTPase binding
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Biological Process:
negative regulation of axonogenesis; negative regulation of protein targeting to membrane; positive regulation of axon extension; protein transport; response to calcium ion; small GTPase mediated signal transduction; vesicle-mediated transport
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Reference #:
P50396
(UniProtKB)
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Alt. Names/Synonyms: GDI-1; Gdi1; GDIA; GDIalpha; guanosine diphosphate (GDP) dissociation inhibitor 1; Guanosine diphosphate dissociation inhibitor 1; MGC21593; OTTMUSP00000019266; Rab GDI alpha; Rab GDIalpha; Rab GDP dissociation inhibitor alpha; Rabgdia
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Gene Symbols: Gdi1
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Molecular weight:
50,522 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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