IMPDH2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family. IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. Note: This description may include information from UniProtKB.
Protein type: EC 1.1.1.205; Nucleotide Metabolism - purine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of mouse Ortholog: 9|9 F2
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  catalytic activity; DNA binding; identical protein binding; IMP dehydrogenase activity; metal ion binding; nucleotide binding; oxidoreductase activity; RNA binding
Biological Process:  'de novo' XMP biosynthetic process; cellular response to interleukin-4; circadian rhythm; GMP biosynthetic process; GMP salvage; GTP biosynthetic process; lymphocyte proliferation; purine nucleotide biosynthetic process
Reference #:  P24547 (UniProtKB)
Alt. Names/Synonyms: IMDH2; IMP dehydrogenase 2; IMP dehydrogenase type II; IMPD; IMPD 2; Impdh; IMPDH 2; IMPDH-II; Impdh2; inosine 5'-phosphate dehydrogenase 2; inosine monophosphate dehydrogenase 2; Inosine-5'-monophosphate dehydrogenase 2
Gene Symbols: Impdh2
Molecular weight: 55,815 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IMPDH2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein