WDR1
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt. Belongs to the WD repeat AIP1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Actin-binding |
Chromosomal Location of mouse Ortholog: 5 B3|5 20.63 cM |
Cellular Component:
actin cytoskeleton; anchoring junction; cell junction; cell projection; cell-cell junction; cortical actin cytoskeleton; cytoplasm; cytoskeleton; plasma membrane
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Molecular Function:
actin binding; actin filament binding
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Biological Process:
actin cytoskeleton organization; actin filament depolymerization; actin filament fragmentation; apical junction assembly; cortical cytoskeleton organization; establishment of planar polarity of follicular epithelium; locomotion; maintenance of epithelial cell apical/basal polarity; neutrophil mediated immunity; neutrophil migration; platelet formation; positive regulation of actin filament depolymerization; regulation of actin filament depolymerization; regulation of cell shape; regulation of oligodendrocyte differentiation; regulation of ventricular cardiac muscle cell membrane repolarization; sarcomere organization; sensory perception of sound
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Reference #:
O88342
(UniProtKB)
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Alt. Names/Synonyms: Actin-interacting protein 1; AIP1; D5Wsu185; D5Wsu185e; red; rede; WD repeat domain 1; WD repeat-containing protein 1; WD40 repeat protein 1; Wdr1
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Gene Symbols: Wdr1
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Molecular weight:
66,407 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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