FPR1
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Belongs to the G-protein coupled receptor 1 family. Neutrophils. Note: This description may include information from UniProtKB.
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Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR |
Chromosomal Location of human Ortholog: 19q13.41 |
Cellular Component:
azurophil granule membrane; cytoplasm; ficolin-1-rich granule membrane; membrane; plasma membrane; secretory granule membrane
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Molecular Function:
complement receptor activity; G protein-coupled receptor activity; G protein-coupled receptor binding; N-formyl peptide receptor activity; protein binding; RAGE receptor binding; scavenger receptor binding
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Biological Process:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway; chemotaxis; complement receptor mediated signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; nitric oxide mediated signal transduction; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; signal transduction
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Reference #:
P21462
(UniProtKB)
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Alt. Names/Synonyms: fMet-Leu-Phe receptor; FMLP; fMLP receptor; formyl peptide receptor 1; FPR; FPR1; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
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Gene Symbols: FPR1
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Molecular weight:
38,446 Da
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Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
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