PAG Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q23
Cellular Component:  integral component of plasma membrane; membrane raft; plasma membrane
Molecular Function:  SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  adaptive immune response; intracellular signal transduction; negative regulation of T cell activation; regulation of T cell activation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q9JM80 (UniProtKB)
Alt. Names/Synonyms: Cbp; Csk binding protein; Csk-binding protein; Pag; Pag1; Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Transmembrane phosphoprotein Cbp
Gene Symbols: Pag1
Molecular weight: 45,915 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept