SMS Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Belongs to the spermidine/spermine synthase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; EC; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - glutathione; Transferase
Chromosomal Location of Human Ortholog: X F4|X 72.48 cM
Cellular Component: 
Molecular Function:  spermine synthase activity
Biological Process:  spermine biosynthetic process; spermine metabolic process
Reference #:  P97355 (UniProtKB)
Alt. Names/Synonyms: AI427066; Gy; gyro; Sms; Spermidine aminopropyltransferase; Spermine synthase; SpmST; SPMSY; SPSY
Gene Symbols: Sms
Molecular weight: 41,313 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene