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PRI2
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. Belongs to the eukaryotic-type primase large subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.7.-; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase |
| Chromosomal Location of mouse Ortholog: 1 12.7 cM|1 B |
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Cellular Component:
alpha DNA polymerase:primase complex; primosome complex
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Molecular Function:
4 iron, 4 sulfur cluster binding; DNA binding; DNA/RNA hybrid binding; iron-sulfur cluster binding; metal ion binding
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Biological Process:
DNA replication; DNA replication initiation; DNA replication, synthesis of RNA primer; positive regulation of DNA primase activity
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Reference #:
P33610
(UniProtKB)
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Alt. Names/Synonyms: AI323589; DNA primase 58 kDa subunit; DNA primase large subunit; DNA primase, p58 subunit; p58; PRI2; Prim2
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Gene Symbols: Prim2
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Molecular weight:
58,408 Da
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Basal Isoelectric point:
8.47
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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