PBEF Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. Belongs to the NAPRTase family. Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC 2.4.2.12; Transferase
Chromosomal Location of mouse Ortholog: 12|12 A3
Cellular Component:  cell junction; cytoplasm; extracellular region; extracellular space; nuclear speck; nucleus; plasma membrane
Molecular Function:  catalytic activity; cytokine activity; drug binding; identical protein binding; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity; transferase activity; transferase activity, transferring glycosyl groups
Biological Process:  circadian regulation of gene expression; circadian rhythm; microglial cell activation; NAD biosynthetic process; negative regulation of autophagy; negative regulation of cellular senescence; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; pyridine nucleotide biosynthetic process; regulation of lung blood pressure; rhythmic process
Reference #:  Q99KQ4 (UniProtKB)
Alt. Names/Synonyms: 1110035O14Rik; AI314458; AI480535; NAmPRTase; Nampt; Nicotinamide phosphoribosyltransferase; PBEF; Pbef1; Pre-B-cell colony-enhancing factor 1 homolog; Visfatin
Gene Symbols: Nampt
Molecular weight: 55,447 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
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PBEF

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene