MDH2 mitochondrial malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. May play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 5 G2|5 75.4 cM
Cellular Component:  cytoplasm; membrane; mitochondrial matrix; mitochondrion
Molecular Function:  catalytic activity; L-malate dehydrogenase activity; malate dehydrogenase (NADP+) activity; malate dehydrogenase activity; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein self-association
Biological Process:  aerobic respiration; carbohydrate metabolic process; carboxylic acid metabolic process; internal protein amino acid acetylation; malate metabolic process; NADH metabolic process; oxaloacetate metabolic process; oxidation-reduction process; tricarboxylic acid cycle
Reference #:  P08249 (UniProtKB)
Alt. Names/Synonyms: malate dehydrogenase 2, NAD (mitochondrial); Malate dehydrogenase, mitochondrial; MDH; Mdh-2; Mdh2; MDHM; mitochondrial malate dehydrogenase 2, NAD; Mor-1; Mor1; OTTMUSP00000026139
Gene Symbols: Mdh2
Molecular weight: 35,611 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MDH2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene