TKT Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Homodimer. Belongs to the transketolase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  endoplasmic reticulum membrane; intracellular membrane-bound organelle; myelin sheath; nuclear body; nuclear speck; nucleoplasm; peroxisome
Molecular Function:  carbohydrate binding; catalytic activity; cofactor binding; magnesium ion binding; metal ion binding; monosaccharide binding; protein homodimerization activity; thiamine pyrophosphate binding; transferase activity; transketolase activity
Biological Process:  glyceraldehyde-3-phosphate biosynthetic process; metabolic process; pentose-phosphate shunt; pentose-phosphate shunt, non-oxidative branch; regulation of growth; ribose phosphate biosynthetic process
Reference #:  P40142 (UniProtKB)
Alt. Names/Synonyms: P68; TK; Tkt; Transketolase
Gene Symbols: Tkt
Molecular weight: 67,630 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TKT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene