PSMB4 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Belongs to the peptidase T1B family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; EC 3.4.25.1; Protease; Proteasome complex
Chromosomal Location of mouse Ortholog: 3 F2.1|3 40.74 cM
Cellular Component:  cytoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function:  endopeptidase activity; hydrolase activity; lipopolysaccharide binding; peptidase activity; threonine-type endopeptidase activity
Biological Process:  negative regulation of inflammatory response to antigenic stimulus; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process
Reference #:  P99026 (UniProtKB)
Alt. Names/Synonyms: Lmp3; Low molecular mass protein 3; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; OTTMUSP00000021272; Pro; Pros-27; proteasome (prosome, macropain) subunit, beta type 4; Proteasome beta chain; Proteasome chain 3; Proteasome subunit beta type-4; PSB4; Psmb4
Gene Symbols: Psmb4
Molecular weight: 29,116 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
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PSMB4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene