GART In the C-terminal section; belongs to the GART family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; EC; EC; Ligase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 16 C3.3|16 53.18 cM
Cellular Component:  cytosol
Molecular Function:  ATP binding; catalytic activity; hydroxymethyl-, formyl- and related transferase activity; ligase activity; metal ion binding; nucleotide binding; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity; transferase activity
Biological Process:  'de novo' IMP biosynthetic process; adenine biosynthetic process; biosynthetic process; glycine metabolic process; metabolic process; purine nucleobase biosynthetic process; purine nucleotide biosynthetic process; response to inorganic substance; response to organic substance; ribonucleoside monophosphate biosynthetic process; tetrahydrofolate biosynthetic process
Reference #:  Q64737 (UniProtKB)
Alt. Names/Synonyms: 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; Gaps; GAR transformylase; GARS; GART; Glycinamide ribonucleotide synthetase; glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide formyltransferase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylamine--glycine ligase; Phosphoribosylformylglycinamidine cyclo-ligase; Phosphoribosylglycinamide formyltransferase; Phosphoribosylglycinamide synthetase; Prgs; PUR2; Trifunctional purine biosynthetic protein adenosine-3
Gene Symbols: Gart
Molecular weight: 107,503 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene