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PFKL
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other |
| Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM |
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Cellular Component:
6-phosphofructokinase complex; cytoplasm; cytosol; membrane
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Molecular Function:
6-phosphofructokinase activity; AMP binding; ATP binding; catalytic activity; fructose binding; fructose-6-phosphate binding; identical protein binding; kinase activity; kinase binding; metal ion binding; monosaccharide binding; nucleotide binding; transferase activity
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Biological Process:
canonical glycolysis; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glycolytic process; glycolytic process through fructose-6-phosphate; metabolic process; negative regulation of insulin secretion; phosphorylation; response to glucose
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Reference #:
P12382
(UniProtKB)
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Alt. Names/Synonyms: 6-phosphofructokinase type B; 6-phosphofructokinase, liver type; AA407869; ATP-dependent 6-phosphofructokinase, liver type; ATP-PFK; K6PL; OTTMUSP00000018445; PFK-B; Pfk-l; PFKAL; Pfkb; Pfkl; Phosphofructo-1-kinase isozyme B; Phosphofructokinase 1; phosphofructokinase, liver, B-type; Phosphohexokinase
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Gene Symbols: Pfkl
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Molecular weight:
85,360 Da
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Basal Isoelectric point:
6.74
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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