DDX5 Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 11 E1|11 70.01 cM
Cellular Component:  catalytic step 2 spliceosome; nucleolus; nucleus; ribonucleoprotein complex; spliceosomal complex
Molecular Function:  androgen receptor binding; ATP binding; ATP-dependent RNA helicase activity; calcium-dependent protein binding; calmodulin binding; enzyme binding; helicase activity; hydrolase activity; MH2 domain binding; mRNA 3'-UTR binding; nucleic acid binding; nucleotide binding; pre-mRNA binding; primary miRNA binding; promoter-specific chromatin binding; protein binding; R-SMAD binding; ribonucleoprotein complex binding; RNA binding; RNA helicase activity; SMAD binding; transcription coregulator activity
Biological Process:  alternative mRNA splicing, via spliceosome; androgen receptor signaling pathway; BMP signaling pathway; circadian rhythm; epithelial to mesenchymal transition; intracellular estrogen receptor signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA processing; mRNA transcription; myoblast differentiation; negative regulation of transcription by RNA polymerase II; nuclear-transcribed mRNA catabolic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of transcription, DNA-templated; pri-miRNA transcription by RNA polymerase II; protein import into nucleus; regulation of alternative mRNA splicing, via spliceosome; regulation of androgen receptor signaling pathway; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; regulation of transcription by RNA polymerase II; regulation of viral genome replication; rhythmic process; RNA splicing
Reference #:  Q61656 (UniProtKB)
Alt. Names/Synonyms: 2600009A06Rik; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 5; Ddx5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5; DEAD box protein 5; DEAD box RNA helicase DEAD1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5; G17P1; Hlr1; HUMP68; mDEAD1; MGC118083; OTTMUSP00000003751; p68; p68 RNA helicase; Probable ATP-dependent RNA helicase DDX5; RNA helicase p68; Tnz2
Gene Symbols: Ddx5
Molecular weight: 69,290 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DDX5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA