|
ZNF24
a transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed in many tissues except in heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 18|18 A2 |
|
Cellular Component:
nucleoplasm; nucleus
|
|
Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding
|
|
Biological Process:
myelination; negative regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
|
|
Reference #:
Q91VN1
(UniProtKB)
|
|
Alt. Names/Synonyms: 3526401F17Rik; 5033419P20Rik; AI480505; AI642085; AL024422; Hmcns; Hypomyelinated CNS protein; KOX1; KOX17; ZF-12; Zfp-191; Zfp19; Zfp191; Zfp24; Zinc finger protein 191; Zinc finger protein 24; Zinc finger protein ZF-12; zinc finger ZF-12; Znf191; Znf24; Znp191
|
|
Gene Symbols: Zfp24
|
|
Molecular weight:
41,919 Da
|
|
Basal Isoelectric point:
5.69
Predict pI for various phosphorylation states
|
