MIF Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Belongs to the MIF family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC; EC; Isomerase
Chromosomal Location of mouse Ortholog: 10 38.59 cM|10 C1
Cellular Component:  cell surface; cytoplasm; cytosol; extracellular region; extracellular space; nucleoplasm; nucleus
Molecular Function:  chemoattractant activity; cytokine activity; cytokine receptor binding; dopachrome isomerase activity; identical protein binding; isomerase activity; phenylpyruvate tautomerase activity; protease binding; protein-containing complex binding; signaling receptor binding
Biological Process:  brain renin-angiotensin system; carboxylic acid metabolic process; cell aging; cell proliferation; cell surface receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; drinking behavior; immune system process; inflammatory response; innate immune response; negative regulation of apoptotic process; negative regulation of cell aging; negative regulation of cell cycle arrest; negative regulation of cellular protein metabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of macrophage chemotaxis; negative regulation of mature B cell apoptotic process; negative regulation of myeloid cell apoptotic process; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of arachidonic acid secretion; positive regulation of axon regeneration; positive regulation of B cell proliferation; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of cytokine secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of glycolytic process; positive regulation of immune response; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of MAP kinase activity; positive regulation of myeloid leukocyte cytokine production involved in immune response; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of potassium ion transport; positive regulation of prostaglandin secretion involved in immune response; positive regulation of protein kinase A signaling; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of tumor necrosis factor production; prostaglandin biosynthetic process; protein homotrimerization; regulation of cell proliferation; spermatogenesis
Reference #:  P34884 (UniProtKB)
Alt. Names/Synonyms: Delayed early response protein 6; DER6; GIF; Glif; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; Macrophage migration inhibitory factor; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MGC107654; MIF; Phenylpyruvate tautomerase
Gene Symbols: Mif
Molecular weight: 12,504 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene