L-plastin Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 14 D3|14 39.63 cM
Cellular Component:  actin cytoskeleton; actin filament; actin filament bundle; cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; filopodium; focal adhesion; glial cell projection; membrane; perinuclear region of cytoplasm; phagocytic cup; plasma membrane; podosome; ruffle; stress fiber
Molecular Function:  actin binding; actin filament binding; calcium ion binding; GTPase binding; integrin binding; metal ion binding; protein binding
Biological Process:  actin filament bundle assembly; actin filament network formation; cell migration; extracellular matrix disassembly; positive regulation of podosome assembly; protein kinase A signaling; regulation of intracellular protein transport; response to wounding; T cell activation involved in immune response
Reference #:  Q61233 (UniProtKB)
Alt. Names/Synonyms: 65 kDa macrophage protein; AW536232; D14Ertd310; D14Ertd310e; L-fi; L-fimbrin; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); LCP-1; Lcp1; Lymphocyte cytosolic protein 1; OTTMUSP00000029452; OTTMUSP00000029453; OTTMUSP00000029783; plastin 2, L; Plastin-2; Pls2; PLSL; pp65
Gene Symbols: Lcp1
Molecular weight: 70,149 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene