|
L-plastin
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 14 D3|14 39.63 cM |
|
Cellular Component:
actin cytoskeleton; actin filament; actin filament bundle; cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; filopodium; focal adhesion; glial cell projection; membrane; perinuclear region of cytoplasm; phagocytic cup; plasma membrane; podosome; ruffle; stress fiber
|
|
Molecular Function:
actin binding; actin filament binding; calcium ion binding; GTPase binding; integrin binding; metal ion binding; protein binding
|
|
Biological Process:
actin filament bundle assembly; actin filament network formation; cell migration; extracellular matrix disassembly; positive regulation of podosome assembly; protein kinase A signaling; regulation of intracellular protein transport; response to wounding; T cell activation involved in immune response
|
|
Reference #:
Q61233
(UniProtKB)
|
|
Alt. Names/Synonyms: 65 kDa macrophage protein; AW536232; D14Ertd310; D14Ertd310e; L-fi; L-fimbrin; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); LCP-1; Lcp1; Lymphocyte cytosolic protein 1; OTTMUSP00000029452; OTTMUSP00000029453; OTTMUSP00000029783; plastin 2, L; Plastin-2; Pls2; PLSL; pp65
|
|
Gene Symbols: Lcp1
|
|
Molecular weight:
70,149 Da
|
|
Basal Isoelectric point:
5.2
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
