RPSA Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (Microbial infection) Acts as a receptor for the Dengue virus. (Microbial infection) Acts as a receptor for the Sindbis virus. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (Microbial infection) Acts as a receptor for the pathogenic prion protein. (Microbial infection) Acts as a receptor for bacteria. Belongs to the universal ribosomal protein uS2 family. Note: This description may include information from UniProtKB.
Protein type: Ribosomal
Chromosomal Location of Human Ortholog: 9 F4|9 71.41 cM
Cellular Component:  basement membrane; collagen-containing extracellular matrix; cytoplasm; cytosol; cytosolic small ribosomal subunit; glutamatergic synapse; membrane; neuronal cell body; nucleus; plasma membrane; ribosome; small ribosomal subunit; synapse
Molecular Function:  laminin binding; laminin receptor activity; ribosome binding; structural constituent of ribosome
Biological Process:  cell-cell adhesion; cytoplasmic translation; ribosomal small subunit assembly; translation
Reference #:  P14206 (UniProtKB)
Alt. Names/Synonyms: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67kDa; 67LR; AL022858; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); Laminin-binding protein precursor p40; LamR; Lamr1; Lamrl1; LBP/p40; LRP/LR; MGC117921; MGC118614; MLR; OFA/iLRP; P40; P40-; P40-3; P40-3, functional; P40-8; P40-8, functional; ribosomal protein SA; Rpsa; RSSA
Gene Symbols: Rpsa
Molecular weight: 32,838 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
Select Structure to View Below

RPSA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene