profilin 1 a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11 B3|11 43.21 cM
Cellular Component:  cell cortex; cytoplasm; cytoskeleton; glutamatergic synapse; neuron projection; nucleus; parallel fiber to Purkinje cell synapse; postsynapse; presynapse; Schaffer collateral - CA1 synapse; synapse
Molecular Function:  actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding; proline-rich region binding; protein binding; Rho GTPase binding; signaling receptor binding
Biological Process:  actin cytoskeleton organization; modification of postsynaptic actin cytoskeleton; negative regulation of actin filament bundle assembly; negative regulation of actin filament polymerization; negative regulation of stress fiber assembly; neural tube closure; positive regulation of actin filament bundle assembly; positive regulation of actin filament polymerization; positive regulation of ATPase activity; positive regulation of DNA metabolic process; positive regulation of epithelial cell migration; positive regulation of ruffle assembly; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; positive regulation of viral transcription; protein stabilization; regulation of actin filament polymerization; regulation of actin polymerization or depolymerization; regulation of transcription by RNA polymerase II; sequestering of actin monomers; synapse maturation
Reference #:  P62962 (UniProtKB)
Alt. Names/Synonyms: actin binding protein; OTTMUSP00000006342; Pfn; Pfn1; PROF1; profilin 1; profilin I; Profilin-1
Gene Symbols: Pfn1
Molecular weight: 14,957 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

profilin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene