LDH-A Homotetramer. Belongs to the LDH/MDH superfamily. LDH family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase
Chromosomal Location of Human Ortholog: 7 B3|7 30.6 cM
Cellular Component:  cytoplasm; cytosol; sperm fibrous sheath
Molecular Function:  catalytic activity; L-lactate dehydrogenase activity; lactate dehydrogenase activity; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding
Biological Process:  carbohydrate metabolic process; carboxylic acid metabolic process; cellular response to extracellular stimulus; glucose catabolic process to lactate via pyruvate; lactate biosynthetic process from pyruvate; oxidation-reduction process
Reference #:  P06151 (UniProtKB)
Alt. Names/Synonyms: L-lactate dehydrogenase A chain; l7R2; lactate dehydrogenase 1, A chain; lactate dehydrogenase A; lactate dehydrogenase A4; lactate dehydrogenase-A; LDH muscle subunit; Ldh-1; LDH-A; LDH-M; Ldh1; Ldha; Ldhm; M-LDH; OTTMUSP00000017774
Gene Symbols: Ldha
Molecular weight: 36,499 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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LDH-A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene