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GEM
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Belongs to the small GTPase superfamily. RGK family. Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, RGK |
| Chromosomal Location of mouse Ortholog: 4 A1|4 5.34 cM |
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Cellular Component:
cytoplasmic side of plasma membrane; membrane; midbody; mitotic spindle; nucleus; plasma membrane; spindle midzone
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Molecular Function:
calcium channel regulator activity; GDP binding; GTP binding; GTPase activity; magnesium ion binding; nucleotide binding; protein binding
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Biological Process:
chromosome organization; metaphase plate congression; mitotic cell cycle; negative regulation of high voltage-gated calcium channel activity
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Reference #:
P55041
(UniProtKB)
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Alt. Names/Synonyms: AV020497; Gem; GTP binding protein (gene overexpressed in skeletal muscle); GTP-binding mitogen-induced T-cell protein; GTP-binding protein GEM; Kir; OTTMUSP00000004868; OTTMUSP00000004869; RAS-like protein KIR
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Gene Symbols: Gem
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Molecular weight:
33,725 Da
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Basal Isoelectric point:
8.74
Predict pI for various phosphorylation states
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