STAT3 iso2 Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Belongs to the transcription factor STAT family. Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  cytoplasm; cytosol; glutamatergic synapse; mitochondrial inner membrane; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; postsynaptic density; RNA polymerase II transcription factor complex; Schaffer collateral - CA1 synapse; transcription factor complex
Molecular Function:  CCR5 chemokine receptor binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; glucocorticoid receptor binding; identical protein binding; nuclear receptor activity; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  acute-phase response; aging; astrocyte differentiation; cell proliferation; cellular response to cytokine stimulus; cellular response to hormone stimulus; cellular response to leptin stimulus; cellular response to organic cyclic compound; cytokine-mediated signaling pathway; eating behavior; energy homeostasis; eye photoreceptor cell differentiation; glucose homeostasis; growth hormone receptor signaling pathway; inflammatory response; interleukin-15-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-9-mediated signaling pathway; intracellular receptor signaling pathway; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; leptin-mediated signaling pathway; miRNA mediated inhibition of translation; modulation of chemical synaptic transmission; mRNA transcription by RNA polymerase II; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cell proliferation; negative regulation of glycolytic process; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of neuron death; negative regulation of neuron migration; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; phosphorylation; positive regulation of angiogenesis; positive regulation of ATP biosynthetic process; positive regulation of cell migration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of gene silencing by miRNA; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 biosynthetic process; positive regulation of metalloendopeptidase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial cell proliferation; postsynapse to nucleus signaling pathway; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of feeding behavior; regulation of mitochondrial membrane permeability; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to estradiol; response to ethanol; response to leptin; sexual reproduction; signal transduction; somatic stem cell population maintenance; T-helper 17 cell lineage commitment; temperature homeostasis; viral process
Reference #:  P40763-2 (UniProtKB)
Alt. Names/Synonyms: Acute-phase response factor; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT3
Gene Symbols: STAT3
Molecular weight: 87,981 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STAT3 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein