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HIPK1
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; DYRK family; EC 2.7.11.1; HIPK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 1p13.2 |
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Cellular Component:
centrosome; cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus; PML body
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Molecular Function:
ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
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Biological Process:
adherens junction assembly; anterior/posterior pattern specification; cell population proliferation; definitive hemopoiesis; embryonic camera-type eye morphogenesis; embryonic retina morphogenesis in camera-type eye; endothelial cell apoptotic process; extrinsic apoptotic signaling pathway; eye development; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; iris morphogenesis; lens induction in camera-type eye; neuron differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of cell population proliferation; protein phosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; retina layer formation; smoothened signaling pathway
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Reference #:
Q86Z02
(UniProtKB)
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Alt. Names/Synonyms: HIPK1; homeodomain interacting protein kinase 1; homeodomain interacting protein kinase 1-like protein; Homeodomain-interacting protein kinase 1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2; nuclear body associated kinase 2b; Nuclear body-associated kinase 2
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Gene Symbols: HIPK1
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Molecular weight:
130,843 Da
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Basal Isoelectric point:
8.48
Predict pI for various phosphorylation states
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