SF3B6 Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. Belongs to the SF3B6 family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component:  nucleoplasm; nucleus; U12-type spliceosomal complex
Molecular Function:  mRNA binding; protein binding
Biological Process:  blastocyst formation; mRNA splicing, via spliceosome
Reference #:  Q9Y3B4 (UniProtKB)
Alt. Names/Synonyms: CGI-110; HSPC175; Ht006; P14; PM14; Pre-mRNA branch site protein p14; SAP14; SAP14a; SF3b 14 kDa subunit; SF3B14; SF3B14a; SF3B6; spliceosome-associated protein, 14 kDa subunit; Spliceosome-associated protein, 14-kDa; Splicing factor 3B subunit 6; splicing factor 3B, 14 kDa subunit; Splicing factor 3b, subunit 6, 14kDa
Gene Symbols: SF3B6
Molecular weight: 14,585 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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